ICSI – Sperm Separation with ZyMoT
ICSI procedure is one of the IVF techniques used in the cases where male infertility issues exist. Briefly, the ICSI procedure consists of a single sperm injected directly into an egg cell.
The next step of evolution in ICSI procedure is the use of sperm separation for the preparation of the sperm injected. Sperm separation is now feasible with the revolutionary devices of ZyMoT. Chania Fertility Unit has already adopted the use of such devices in the ICSI procedure, enhancing the quality and the successful rates of the procedure.
What is Sperm Separation
ZyMot device is an innovation which enables collecting the best-performing sperm for use in ART procedures, leading eventually in better results for the patients.
These devices, used in Chania Fertility Centre, prepare motile sperm from semen for use in various ART procedures, such as ICSI, IUI and IVF.
There are up to 80% fewer hands-on tech hours needed with ZyMot devices, which reduces the possibility of human error. There is less variation among lab staff since sperm separation in clinical settings may be regulated and there is no pretreatment required.
The cutting-edge ZyMoT devices replicate the uterine and cervical natural barriers that sperm must cross in order to fertilize an egg.
Sperm Separation results
- Reduction of DNA fragmentation and reactive oxygen species production
- Sperm Mobility increase
- Fertility success increase
ΖyMoT devices comparing with the traditional procedures of sperm separation:
- they avoid density-gradient centrifugation (DCG) and also preserve normal sperm morphology, succeeding in the reduction of DNA fragmentation and reactive oxygen species (ROS) production
- they isolate the best quality sperm – the healthiest and the most rapidly progressive.
- Increased fertility and euploidy rates.
- providing considerable time savings and standardization over conventional methods
Chania Fertility Centre uses ZyMoT devices successfully, improving ART procedures and, specifically, the quality of sperm used in IVF and ICSI treatments.
Relative Bibliography
- Asghar, W., Velasco, V., Kingsley, J. L., Shoukat, M. S., Shafiee, H., Anchan, R.M., Mutter, G. Tuzel, E. And Demirci, U. (2014), Selection of Functional Human Sperm with Higher DNA Integrity and Fewer Reactive Oxygen Species. Adv. Healthcare Mater., 3: 1671-1679. doi: 10.1002/adhm.201400058
- A.P. Dimakopoulou et al. Elevated semen oxidative stress in male partners as novel marker of recurrent pregnancy loss. ENDO 2019, New Orleans, March 24, 2019.
- C.N. Jayasena et al. Reduced testicular steroidogenesis and increased semen oxidative stress in male partners as novel marker of recurrent miscarriage. Clinical Chemistry. Volume 65, January 2019, p. 161.
- M.M. Quinn et al. Microfluidic sorting selects sperm for clinical use with reduced DNA damage compared to density gradient centrifugation with swim-up in split semen samples. Hum Reprod. July 10, 2018. doi: 10.1093/humrep/dey239.
- A. Broussard et al. Sperm DNA fragmentation (SDF) was most effectively improved by a sperm separation device compared to different gradient and swim-up methods. PCRS 2019, Indian Wells, April 5, 2019.
