Ovarian Rejuvenation (PRP) treatment

A Modern Approach to Supporting Ovarian Function

Ovarian rejuvenation with Platelet-Rich Plasma (PRP) is an innovative fertility treatment designed to support ovarian function in selected women experiencing reduced ovarian reserve, low AMH levels, diminished ovarian response, or age-related fertility decline. By utilizing the regenerative properties of platelets derived from the patient’s own blood, ovarian rejuvenation aims to create a favorable environment within the ovaries and may contribute to improved ovarian activity in carefully selected cases.

At Chania Fertility Unit, ovarian rejuvenation is incorporated into a personalized fertility strategy that may also include IVF, ICSI, fertility preservation, and other advanced reproductive techniques, depending on each patient’s unique medical history and reproductive goals. Dr Fraidakis comes with an extensive experience in applying ovarian rejuvenation since 2016, being a pioneer in this regenerative medicine field with significant successful results.

What Is Ovarian Rejuvenation?

Ovarian rejuvenation is a minimally invasive procedure that involves the collection of a small blood sample from the patient. Through a specialized laboratory process, platelet-rich plasma (PRP) is isolated and concentrated. This PRP contains growth factors and bioactive molecules naturally involved in tissue repair and cellular signaling.

The concentrated PRP is then carefully introduced into the ovaries under ultrasound guidance by an experienced fertility specialist.

The objective of the procedure is to support the ovarian microenvironment and potentially enhance ovarian activity in selected patients.

Who May Benefit from Ovarian Rejuvenation?

Ovarian rejuvenation may be considered for women who experience:

  • Low ovarian reserve
  • Low Anti-Müllerian Hormone (AMH) levels
  • Elevated FSH levels
  • Poor ovarian response during IVF stimulation
  • Repeated IVF cycle cancellations due to insufficient follicular development
  • Age-related decline in ovarian function
  • Early ovarian aging
  • Premature ovarian insufficiency (selected cases)
  • Women seeking additional fertility-supportive options before IVF treatment

A thorough fertility evaluation is essential to determine whether ovarian rejuvenation may be appropriate for each individual case.

How Does PRP Work?

Platelet-rich plasma contains naturally occurring growth factors that participate in tissue regeneration, angiogenesis, and cellular communication. Researchers are investigating whether these biological mechanisms may positively influence ovarian tissue and follicular development.

Although scientific studies continue to explore the role of PRP in reproductive medicine, ovarian rejuvenation has emerged as a promising area of fertility research and clinical interest worldwide.

The Ovarian Rejuvenation Procedure

The treatment is typically performed on an outpatient basis and generally involves the following steps:

Step 1: Blood Collection

A small amount of blood is drawn from the patient.

Step 2: PRP Preparation

The blood sample is processed using specialized centrifugation techniques to isolate and concentrate platelets.

Step 3: Ultrasound-Guided Administration

Using transvaginal ultrasound guidance, the PRP is carefully introduced into the ovarian tissue.

Step 4: Follow-Up Monitoring

Patients undergo regular monitoring of ovarian function through ultrasound examinations and hormonal testing, including AMH, FSH, estradiol, and antral follicle count assessment.

Benefits of Ovarian Rejuvenation

Depending on individual circumstances, ovarian rejuvenation may potentially contribute to:

  • Support of ovarian function
  • Improvement in ovarian response during fertility treatment
  • Increased follicular activity
  • Enhanced IVF treatment planning opportunities
  • Additional reproductive options for women with diminished ovarian reserve
  • Personalized fertility optimization strategies

Results vary significantly among patients, and no fertility treatment can guarantee pregnancy or specific reproductive outcomes.

Ovarian Rejuvenation and IVF

Many women explore ovarian rejuvenation as part of a broader IVF treatment plan. In selected cases, fertility specialists may recommend PRP treatment before initiating an IVF cycle to assess potential changes in ovarian response.

At Chania Fertility Unit, treatment recommendations are individualized and based on comprehensive fertility assessment, reproductive history, age, ovarian reserve testing, and previous treatment outcomes.

Safety and Recovery

Because PRP is prepared from the patient’s own blood, the risk of allergic reaction is minimal. The procedure is generally well tolerated and performed under appropriate medical supervision.

Most patients return to normal daily activities shortly after treatment, although individual recovery experiences may vary.

Why Choose Chania Fertility Unit for Ovarian Rejuvenation?

At Chania Fertility Unit, ovarian rejuvenation is performed within a comprehensive fertility care framework that combines:

  • Advanced IVF and ICSI techniques
  • Individualized fertility assessment
  • State-of-the-art embryology laboratory services
  • Evidence-based reproductive medicine
  • Personalized treatment planning
  • Continuous patient support throughout the fertility journey

Our goal is to provide innovative fertility solutions while maintaining the highest standards of safety, scientific integrity, and patient-centered care.

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