Stem Cell therapy
Stem Cell Therapy is an emerging treatment of reproductive medicine used to support tissue regeneration, improve the reproductive microenvironment, and optimize fertility treatment strategies in selected clinical situations.
Using the patient’s own stem cells, stem cell therapy can address the reduced ovarian reserve (infertility) issue without any dangers or adverse consequences.
It can be used for any woman with reduced ovarian reserve. In cases of reduced ovarian reserve, stem cell therapy has a success rate of at least 72%.
What is Stem Cell therapy
Stem cells are specialized cells with the ability to self-renew and to support the repair and regeneration of damaged tissues through complex biological signaling mechanisms.
In regenerative reproductive medicine, the most commonly used cells are autologous mesenchymal stem cells, which are typically obtained from the patient’s own adipose (fat) tissue or bone marrow.
These cells release numerous bioactive molecules, growth factors, cytokines, and extracellular vesicles that may contribute to tissue repair, angiogenesis, modulation of inflammation, and cellular communication.
Because the cells originate from the patient’s own body, the risk of immune rejection is minimized.
What is the ovarian reserve that affects Stem cell therapy
The quantity of eggs in a woman’s ovaries is referred to as her ovarian reserve. A woman’s ovaries contain a large number of eggs, or follicles, if she has a high ovarian reserve.
A woman’s ovarian reserve, or the follicles (eggs) that produce fertility, starts to decline with age, particularly beyond the age of 35. The fact that there are roughly the same amount of eggs does not mean that the woman’s eggs are good enough to produce a healthy child.
Improper inflammation leads to inappropriate folliculogenesis in patients with ovarian dysfunction because their ovaries exhibit persistent chronic inflammation with a large number of lymphocytes and macrophages.
In addition to producing a significant number of multipotent adipose-derived stromal cells (ADSCs), adipose/fat tissue offers an abundant source of stromal vascular fraction (SVF) cells for rapid injection. In the field of regenerative medicine, SVF and ADSCs have both recently acquired broad translational significance.
How Stem Cell therapy works
Hormonal level recovery, follicular stimulation, ovarian angiogenesis, and functional restoration are all possible outcomes of stem cell therapy.
All of our body’s tissues and organs are composed of stem cells, which are natural healers with the capacity to divide endlessly, regenerate, and treat our entire body. As a result, it can be used to treat female infertility.
The patient’s age, the length of the illness, and their health all affect how well the treatment works. All endocrinological tests and examinations must be carried out since the sickness may have started as a result of an endocrine system issue.
The patient’s weight and age define how many cells should be given. Mesenchymal stem cells, which are derived from the patient’s own adipose tissue, are used in treatment. The patient’s condition determines the course of treatment.
By promoting tissue repair, adipose tissue is processed unaltered and reduced to a micro solution that may be applied to tissues right away. We inject 10 ml of the whole solution, which contains 2,800,000 to 20,000,000 live cells in a 1 ml suspension. We are the only ones who employ a particular apparatus that ensures the quantity of stem cells per milliliter. As a result, this approach is far more successful than others.
Using a closed syringe lipoaspiration system with disposable microcanulas provides a safe and efficient way to extract small amounts of adipose tissue and the stem cells that go along with it. This is accomplished by aspirating the patient’s fat, which is placed in a laminar airflow bench, using a needle and syringe. Local anesthesia or mild sedation is used for this treatment.
Increasing the quantity and/or quality of eggs in the ovary has a success rate of at least 72%.
Who are the candidates for Stem Cell Therapy?
Following a comprehensive medical assessment, Stem Cell therapy may be considered for patients experiencing:
- Low ovarian reserve
- Low AMH
- Poor ovarian response
- Premature ovarian insufficiency
- Early menopause
- Thin endometrium
- Recurrent implantation failure
- Male infertility
- Oligospermia
- Vaginal tissue changes associated with menopause or childbirth
Treatment eligibility is determined individually after evaluation by an experienced reproductive medicine specialist.
Benefits of Stem Cell Therapy
The following are the outcomes of Stem Cell therapy:
- An increase in AMH levels
- Decrease in FSH levels
- Increaseof E2 levels
- An increase in the ovary’s size
- Ovarian function restoration
- Follicle formation stimulation (increase in AFC)
- Menstruation has resumed
- Rising rates of pregnancy
Depending on the clinical indication, Stem Cell therapy contributes to:
- Support of ovarian function
- Improved ovarian microenvironment
- Enhanced endometrial regeneration
- Better tissue vascularization
- Optimization of fertility treatment planning
- Improvement in vaginal tissue quality
- Personalized regenerative fertility care
